2-Methyl-4-phenyl-3,4-dihydroquinazoline
نویسندگان
چکیده
The title compound, C(15)H(14)N(2), was formed during the lithia-tion of 2-methyl-quinazoline with phenyl-lithium followed by hydrolysis of the inter-mediate lithium 2-methyl-4-phenyl-4H-quinazolin-3-ide. NMR spectra as well as single-crystal X-ray structural data indicate that the reaction product to have the same structure in chloro-form solution as in the crystalline state. The phenyl substituent is twisted out of the plane of the 3,4-dihydro-quinazoline ring system by 86.47 (7)°. In the crystal, inter-molecular N-H⋯N inter-actions connect the mol-ecules into infinite chains.
منابع مشابه
SYNTHETIC STUDIES IN THE 6H-[1,2,4] TRIAZINO [3,4-b] [ 1,3,4] THIADIAZINES
4-Amino-6-methyl- 1,2,4-triazine-3(2H)-thione-5-0ne (1) was condensed with propargyl bromidein the presence of sodium rnethoxide to afford 3-propargylmercapto- 4-arnino-6-rnethyl-1,2,4-triazin-5-one(2) . Transformation of the latter to 8-dihydro- 3-methyl-7-methylene-4-oxo-6H-[1,2,4]TRIAZINO [3,4-b] [1,3,4] thiadiazine (3) was performed under the condition of palladium (II) salt. Ring closu...
متن کاملTwo isomeric 10-methyl-8-phenyl-11-pyridyl-6,8-dihydro-5H-benzo[f]pyrazolo[3,4-b]quinolines: cyclic hydrogen-bonded tetramers versus isolated molecules.
The molecules of 10-methyl-8-phenyl-11-(3-pyridyl)-6,8-dihydro-5H-benzo[f]pyrazolo[3,4-b]quinoline, C26H20N4, (I), are linked by a single C-H...N hydrogen bond into cyclic R(4)(4)(12) tetramers generated by a -4 axis. In isomeric 10-methyl-8-phenyl-11-(4-pyridyl)-6,8-dihydro-5H-benzo[f]pyrazolo[3,4-b]quinoline, (II), which crystallizes with Z' = 2 in space group P2(1)2(1)2, the two independent ...
متن کامل4-Methyl-1,3-bis(3,4-methylenedioxybenzyl)-2-(3,4-methylenedioxyphenyl)imidazolidine
In the title compound, C(27)H(26)N(2)O(6), the imidazolidine ring adopts an envelope conformation. The methyl group on the imidazolidine ring is disordered over two positions with occupancies of 0.517 (11) and 0.483 (11), and the 3,4-methyl-enedioxy-phenyl at the 3-position of imidazolidine ring is also disordered over two positions with occupancies of 0.60 (2) and 0.40 (2).
متن کاملSynthesis, anti-inflammatory and analgesic evaluation of thioxoquinazolinone derivatives.
A series of 3-substituted-2-thioxoquinazolin-4(3H)-one derivatives have been synthesized and their structures have been elucidated on the basis of IR, (1)H-NMR, elemental analysis and mass spectroscopic studies. Anti-inflammatory and analgesic activity of the synthesized compounds was evaluated by Carrageenan induced rat paw edema method and Eddy's hot plate method respectively. Among the synth...
متن کاملSynthesis and biological evaluation of some novel pyrazolopyrimidines incorporating a benzothiazole ring system.
In the present study, a series of benzothiazol derivatives 3a-l containing pyrazolo[3,4-d]pyrimidine moiety at the second position were synthesized and characterized by analytical and spectral data. The compounds were tested for their in vitro antimicrobial activity. Compounds 1-(1,3-benzothiazol-2- yl)-3-methyl-4-phenyl-1H-pyrazolo[3,4-d]pyrimidine (3a), 1- (1,3-benzothiazol-2-yl)-4-(4-chlorop...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 67 شماره
صفحات -
تاریخ انتشار 2011